Treatment Clinical Trials for Pancreatic Cancer Clinical trials are research studies that involve people. The purpose of this study is to assess the best 2-year overall survival when comparing fluorouracil, irinotecan hydrochloride, and oxaliplatin (combination chemotherapy) to gemcitabine hydrochloride and nab-paclitaxel, given before surgery for treating patients who have pancreatic cancer that can be removed by surgery. The purpose of this study is to determine the safety and pharmacokinetic profile of nab® -paclitaxel (ABI-007) plus gemcitabine in subjects with advanced pancreatic cancer who have cholestatic hyperbilirubenemia secondary to bile duct obstruction. Clinical trials for pancreatic cancer may include: finding ways to diagnose pancreatic cancer at an earlier stage finding better ways of giving existing treatments – for example, combining different chemotherapy drugs or giving combinations in different ways That’s why experts say clinical trials are a pancreatic cancer patient’s best treatment option. Learn how surgeons and oncologists at the Medical College of Wisconsin have developed a unique personalized medicine clinical trial for pancreatic cancer. The purpose of this study is to develop a data-driven approach that enables healthcare providers to “prescribe” exercise in the appropriate dose in a manner analogous to prescribing a drug. As part of this goal, we’ve worked for decades to find new options for people with pancreatic cancer who are not helped by the usual treatments. Clinical trials are research studies that are done to investigate new treatments through the observation of patients. Purpose of this phase I/II study is to test how well LY2090314 works in combination with different chemotherapies in treating participants with metastatic pancreatic cancer. Many of our innovations and approaches have set the standard for care of this disease around the world. In clinical trials, the idea is to alter the tumor’s environment by treating patients with the drug cyclophosphamide before giving patients the vaccine, making the tumor more responsive to the vaccine. The purpose of this study is to assess the ability to successfully create numerous validated patient-derived xenograft (PDX) models from patient tumor specimens obtained at surgery/biopsy via the new Pathology/TRAG cryopreservation protocol, and to generate a large catalog and repertoire of previously unavailable histologically validated PDX. open to eligible people ages 18 years and up . The purpose of this study is to evaluate the effectiveness and safety of Folfirinox (FFX) versus CPI-613 + Modified Folfirinox (mFFX) in patients with metastatic adenocarcinoma of the pancreas. In this study, participants with pancreatic cysts will undergo endoscopic ultrasound (EUS) guided ethanol injection of pancreatic cysts. This is a multicenter, open-label, Phase 1, dose escalation trial to evaluate the safety, tolerability, and recommended Phase 2 dose (RP2D) of TH-302 in combination with gemcitabine and nab-paclitaxel in previously untreated subjects with locally advanced unresectable or metastatic pancreatic adenocarcinoma. The purpose of this study is to to evaluate the rate of overall survival (OS) at two years in patients with either borderline or locally advanced pancreatic cancer who receive electron beam intraoperative radiation therapy (IORT) following chemotherapy and radiation therapy. Restaging and imaging studies will be performed to assess disease relapse per NCCN guidelines. 76 in progress, 44 open to eligible people . The purpose of this study is to evaluate the safety and clinical activity of the combination of durvalumab with CV301 in combination with maintenance chemotherapy for patients with metastatic colorectal or pancreatic cancer whose disease is stable on, or responding to 1st line therapy for metastatic disease. Specifically, FNB will increase the proportion of cases in which sufficient DNA is obtained to allow genomic profiling and whole exome sequencing. This randomized phase II-R/III trial studies gemcitabine hydrochloride with or without erlotinib hydrochloride followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery. Drugs used in chemotherapy, such as GDC-0449 and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. This is a randomized, open-label, multi-center, phase 3 study of napabucasin plus weekly nab-paclitaxel with gemcitabine versus weekly nab-paclitaxel with gemcitabine for adult patients with Metastatic Pancreatic Ductal Adenocarcinoma. This is a phase II multi-center study of nab-paclitaxel, gemcitabine and cisplatin (NGC triple regimen) as preoperative therapy in potentially resectable pancreatic cancer patients. Patients with metastatic cancer and weight loss sometimes are not able to receive treatment due to physical weakness or debility. All rights reserved. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Weight loss occurs in pancreatic cancer patients and is common in a multitude of other cancers. This sample-collection study is open to participants in several categories: healthy volunteers (with or without a family history of pancreatic cancer) and individuals diagnosed with pancreatitis or any stage of pancreatic cancer. Subjects who complete the treatment will choose, with their treating physicians, what additional treatment should be given: more nab-Paclitaxel plus gemcitabine, Chemoradiation therapy, or surgery to treat the locally advanced pancreatic cancer. Mayo Clinic does not endorse any of the third party products and services advertised. At Memorial Sloan Kettering, our mission has always been a singular one: to care for and cure people with cancer. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms, Evaluation of PCLs Using Three EUS-FNA Needles, Optical and Biochemical Biomarkers in Early Pancreatic Cancer, Evaluating Markers which Might be a Predictor of Pancreatic Cancer or Precancer by Analyzing the Secretions (fluid) from a Pancreatic cyst, A Study to Compare Colon Lavage Fluids for Pancreatic Cancer Marker Validation, Phase II Randomized Trial of mFOLFIRINOX +/- Ramucirumab in Advanced Pancreatic Cancer, Phase 2 Nab®-Paclitaxel (Abraxane®) Plus Gemcitabine in Subjects with Locally Advanced Pancreatic Cancer (LAPC), Phase II Study of NGC-Triple Regimen in Potentially Resectable Pancreatic Cancer Patients, Exploring Duodenal Biopsies as a Biomarker of Pancreatic Cancer, American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry, A Study of Endoscopic Ethanol Ablation of Communicating Pancreatic Cystic Neoplasms, Nab-paclitaxel and Gemcitabine vs Gemcitabine Alone as Adjuvant Therapy for Patients with Resected Pancreatic Cancer (the "Apact" Study). This is a phase II, multicenter, double-blinded, randomized, 2-arm trial evaluating the efficacy and safety of mFOLFIRINOX plus ramucirumab (Arm A) vs. mFOLFIRINOX plus placebo (Arm B) in 94 subjects with advanced pancreatic cancer, not amenable to curative treatment. Evaluate the comparative performance of blood and FDG PET-MRI/MRCP based biomarkers for assessment of response to neoadjuvant therapy in borderline resectable PDAC. Clinical trials are research studies that investigate new treatments or new combinations of treatments. This study will evaluate feasibility and acceptability of providing the Dignity Therapy/Life Plan intervention to pancreatic or advanced lung cancer patients presenting for treatment in the outpatient medical oncology setting. All ages Under 18 Over 18. Sirolimus and vismodegib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The purpose of this study is to understand the interplay of factors increasing susceptibility and expression of pancreatic cancer and melanoma to develop new diagnostic and chemopreventive regimens. In addition, this study will also assess the pharmacokinetic (PK) profile and preliminary efficacy of SBP-101. This clinical study is in subjects who are 18 years old or older with locally advanced pancreatic cancer who have not received prior treatment for their pancreatic cancer. The purpose of this study is to evaluate TST001, a recombinant humanized anti-Claudin 18.2 (CLDN18.2) IgG1 monoclonal antibody, to treat advanced and/or metastatic solid tumors including gastric, gastroesophageal junction, pancreatic, colon and lung cancers. The study treats all subjects with nab-Paclitaxel plus gemcitabine for approximately 6 months of treatment. The purpose of this study is to evaluate molecular markers which might be a predictor of pancreatic cancer or precancer by analyzing the secretions (fluid) from a pancreatic cyst, pancreas fluid and tissue from a resected pancreatic cyst. A Multi-center Trial to Evaluate Multiple Regimens in Metastatic Pancreatic Cancer open to eligible people ages 18 years and up Precision Promise is a multi-center, seamless Phase 2/3 platform trial designed to evaluate multiple regimens in metastatic pancreatic cancer. The purpose of this study is to evaluate the side effects and how well the combination of binimetinib and encorafenib work in treating patients with pancreatic cancer with a somatic BRAF V600E mutation. The purpose of this study is to evaluate the effects of treating pancreas cysts that connect with the main pancreas duct with injected ethanol using endoscopic retrograde cholangiopancreatography (ERCP) and/or endoscopic ultrasound. The Pancreatic Cancer Collective is accelerating research for pancreatic cancer patients who desperately need better treatments. The purpose of this study is to characterize the safety and tolerability of combined treatment with mogamulizumab and nivolumab, and also determine the maximum tolerated dose and the recommended fixed dose for the treatment of patients who have locally advanced or metastatic solid tumors. For many patients, clinical trials may be a potential option to access experimental and cutting edge therapy. This phase I trial studies the side effects and best dose of gemcitabine hydrochloride in treating patients with locally advanced pancreatic cancer. Trials are carefully monitored scientific studies that involve patients and offer … The main purpose of the safety lead-in (dose-finding) part of the study is to determine the safety and tolerability of anetumab ravtansine in combination with cisplatin and in combination with gemcitabine, and to determine the MTD of anetumab ravtansine in combination with cisplatin for mesothelin expressing advanced cholangiocarcinoma and in combination with gemcitabine for mesothelin expressing advanced adenocarcinoma of the pancreas. The purpose of this study is to determine whether an investigational immuno-therapy, cabiralizumab in combination with nivolumab, with or without chemotherapy, is effective for the treatment of advanced pancreatic cancer. Evaluation of quantitative biomarkers derived from simultaneous time-of-flight FDG PET-MRI/MRCP for assessment of response to neoadjuvant therapy in borderline resectable PDAC. Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN, Rochester, MN; Jacksonville, FL; Scottsdale/Phoenix, AZ, Scottsdale/Phoenix, AZ; Rochester, MN; Jacksonville, FL, Rochester, MN; Scottsdale/Phoenix, AZ; Rochester, MN, Eau Claire, WI; Rochester, MN; Mankato, MN; La Crosse, WI, Eau Claire, WI; Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN, Jacksonville, FL; Scottsdale/Phoenix, AZ; Rochester, MN. The study treats all subjects with nab-Paclitaxel plus gemcitabine for approximately 6 months of treatment. All participants will submit urine, saliva and blood samples; pancreatitis and pancreatic cancer patients will also submit tissue samples if biopsy/ies or surgery is part of the care being provided by their doctor. ), Pancreatic Cancer Clinical Trials & Research, exploring new techniques to reduce possible complications of, © 2021 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Pancreatic Cancer Surgeons, Doctors & Experts, A Phase I Study of AB680 in Combination with AB122 Immunotherapy, Nab-Paclitaxel, and Gemcitabine in People with Advanced Pancreatic Cancer, A Phase I Study of BI 905711 in People with Advanced Digestive Cancers, A Phase I Study of CDX-1140 Immunotherapy in Patients with Advanced Cancer, A Phase I Study of HPN536 in Patients with Advanced Cancers, including Mesothelioma, Pancreatic Cancer, and Ovarian Cancer, that Continue to Grow Despite Standard Therapy, A Phase I Study of MVT-1075 Radioimmunotherapy in Patients with Recurrent or Persistent Pancreatic Cancer, A Phase I Study of MVT-5873 Alone or with Chemotherapy in Patients with Pancreatic Cancer and Other CA19-9 Positive Tumors, A Phase I Study of Personalized Tumor Vaccines and Atezolizumab Immunotherapy in Patients with Operable Pancreatic Cancer, A Phase I Study of RGX-202-01 with or without FOLFIRI in Patients with Advanced Digestive Cancers, A Phase I/II Study of BA3011 in Patients with Advanced Cancer, Metastatic Disease after Hormone-Reducing Therapy, A Phase I/II Study of GB1275 Immunotherapy Alone, with Pembrolizumab Immunotherapy, or with Nab-paclitaxel and Gemcitabine in Patients with Advanced Digestive Cancers, Targeting Pancreatic Cancer: An Increased Focus on Developing New Clinical Trials, Pancreatic Research Center Takes a Transformative Approach, David M. Rubenstein Center for Pancreatic Cancer Research, Cancer Genomics: New Technologies Speed Discovery and Expand Opportunities for Personalized Medicine. Materials and methods: We queried https://clinicaltrials.gov/ for registered pancreatic cancer clinical trials. The Pancreatic Cancer Action Network strongly recommends clinical trials at diagnosis and during every treatment decision. The purpose of this study is to learn more about pancreatic cancer genetics in association with response to drug therapy. Groce joined the clinical trial as a phase I study participant. The purpose of this study is to determine whether oral rucaparib is effective in the treatment of patients with locally advanced or metastatic pancreatic cancer and a known deleterious BRCA mutation. Although unselected trials in pancreatic cancer with immunotherapy alone have yet to be successful, we hypothesize that ... Test the safety, immune response and efficacy of GVAX pancreas vaccine (with cyclophosphamide) and CRS-207 compared to chemotherapy or CRS-207 alone in adults with previously treated metastatic pancreatic adenocarcinoma. The purpose of this study is to compare the proteomic markers from gastrointestinal lavage fluid collected from patients with a pancreatic mass to a control group of otherwise healthy subjects. The primary purpose of this study is to obtain de-identified, clinically characterized, whole blood specimens to evaluate biomarkers associated with cancer for diagnostic assay development. BPM31510 Administered Intravenously With or Without Gemcitabine in Advanced Pancreatic Cancer Patients, A Study of LY2090314 and Chemotherapy in Participants with Metastatic Pancreatic Cancer, A Study to Analyze the Safety and Effectiveness of the NanoKnife® System in Unresectable Stage 3 Pancreatic Adenocarcinom Patients, Perioperative Therapy for Resectable and Borderline-Resectable Pancreatic Adenocarcinoma With Molecular Correlates, Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients with Pancreatic Cancer That Has Been Removed by Surgery, High-Dose Radiation Therapy Versus Standard Care in Treating Patients With Pancreatic Cancer That Cannot Be Removed By Surgery, Pharmacokinetic and Safety Study of Nab ®-Paclitaxel (ABI-007) Plus Gemcitabine in Subjects with Advanced Pancreatic Cancer Who Have Cholestatic Hyperbilirubenemia, A Study to Evaluate Binimetinib in Combination with Encorafenib in Patients with Pancreatic Malignancies and a Somatic BRAFV600E Mutation, A Study to Evaluate the Diagnostic Potential of a Lateral Flow Assay to Detect QSOX1 Peptide in Patients With or At Risk for Pancreatic Cancer, Study Assessing Safety and Efficacy of Combination of BL-8040 and Pembrolizumab in Metastatic Pancreatic Cancer Patients (COMBAT/KEYNOTE-202), Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma, Evaluating FDG PET-MRI-based Biomarkers in Borderline Resectable Pancreatic Cancer, A Study of ACP-196 Alone and in Combination with Pembrolizumab in Subjects with Advanced or Metastatic Pancreatic Cancer, International Multicenter Registry of Cancer of the Pancreas Screening, Dignity Therapy/Life Plan in Patients With Pancreatic or Advanced Lung Cancer, Gemcitabine Hydrochloride in Treating Patients with Locally Advanced Pancreatic Cancer, A Study of BBI608 Combined with Standard Chemotherapies in Adult Patients who have Pancreatic Cancer, PERT for Treatment of Exocrine Pancreatic Insufficiency in Patients With Unresectable Pancreatic Cancer, A Study to Increase Understanding About Pancreatic Cancer Genetics and Response to Drug Therapy, A Study to Evaluate BXCL701 Combined with PD-L1 Mab Avelumab (Bavencio) and Bempegaldesleukin (NKTR-214) in Patients with This is a Phase 2 multicenter, open-label, non-randomized study to examine the safety and effectiveness of BPM31510 administered as a 144-hour continuous intravenous (IV) infusion as a monotherapy or in combination with gemcitabine in advanced pancreatic cancer patients as 2nd / 3rd line therapy. This clinical study is in subjects who are 18 years old or older with locally advanced pancreatic cancer who have not received prior treatment for their pancreatic cancer. In this clinical trial a patient’s tumor is tested extensively to identify which chemotherapy treatment has the greatest chance of successfully treating the cancer. Furthermore, a maximal synergetic effect was achieved when a FAK inhibitor was given in combination with a PD-1 antagonist and chemotherapy in multiple pancreas tumor animal models. If your doctor suspects pancreatic cancer, he or she may have you undergo one or more of the following tests: 1. The purpose of this study is to observe adverse events and effectiveness of hypofractionated concurrent chemoradiotherapy for the treatment of pancreatic cancer. The purpose of this study is to develop a test for detection of pancreatic cancer by looking at the subject's DNA. A single copy of these materials may be reprinted for noncommercial personal use only. This study will also learn more about how the combination of these two investigational drugs may work for patients with certain cancers (specifically metastatic breast cancer, advanced pancreatic adenocarcinoma, metastatic colorectal cancer and recurrent glioblastoma multiforme). Why Some People in Families Develop Melanoma or Pancreas Cancer, While Still Others Never Develop Cancer, Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers, A Study of AbGn-107 in Patients With Gastric, Colorectal, or Pancreatic Cancer, Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer, A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens, Safety Study of Nivolumab With Nab-Paclitaxel Plus or Minus Gemcitabine in Pancreatic Cancer, Nab-Paclitaxel / Carboplatin in Stage IIIB/IV Non-Small Cell Lung Cancer or Nab-Paclitaxel in Recurrent Metastatic Breast Cancer, A Study of Intravital Microscopy (IVM) in Human Solid Tumors, A Study to Evaluate ATRC-101 in Adults with Advanced Solid Malignancies, MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to Treatment, A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer, A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors, Aggressive Malignancy PDX (Avatar) and Cryopreservation Program, A Study of Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma, A Study of Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors, Establishment of a Biorepository of Baseline and Follow-up Saliva Samples Collected from Newly Diagnosed, Treatment-naïve Cancer Patients, A Study to Evaluate Precision Pharmacogenomics in Cancer Patients, A Study to Evaluate the Effectiveness and Safety of Rivaroxaban as Prophylaxis Treatment for Venous Thromboembolism (VTE) in Ambulatory Cancer Patients, Temsirolimus and Bevacizumab in Treating Patients with Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer, A Study of Sonidegib and Pembrolizumab in Advanced Solid Tumors, A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Subjects With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723), hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse, A Study of Mogamulizumab Combined with Nivolumab in Patients who have Locally Advanced or Metastatic Solid Tumors, Mayo Clinic Cancer Genomics Service Line Biorepository, A Phase 1/2 Study of CYT-0851, an Oral RAD51 Inhibitor, in B-Cell Malignancies and Advanced Solid Tumors, A Study to Evaluate the Challenges, Behavioral Patterns, and Preferences of Minority Patient Participation in Clinical Trials, A Study to Evaluate Exercise for Cancer Patients at Risk of Falling, The Circulating Cell-free Genome Atlas Study, Advertising and sponsorship opportunities. The research will be conducted at Baylor College of Medicine (BCM) and Baylor St. Luke's Medical Center (BSLMC). This is a Phase I, open label study to evaluate the safety, tolerability, and immunogenicity of INO-1400 alone or in combination with INO-9012, delivered by electroporation in subjects with high-risk solid tumor cancer with no evidence of disease after surgery and standard therapy. These tests help your doctors visualize your internal organs, including the pancreas. Subjects will be enrolled into one of six treatment arms. The purpose of this study is to assess DNA markers in pancreatic juice and stool for the detection of pancreatic cancer and precancer. The purpose of this study is to create a prospective cohort of subjects with increased probability of being diagnosed with pancreatic cancer and then screen this cohort for pancreatic cancer. RECIST will be used to validate the findings in cases of relapse. This is an open-label, nonrandomized, Phase 1/2 study in subjects with advanced or metastatic solid tumors. The purpose of this study is to compare whether there is a delay or prevention of recurrence or death in subjects with surgically removed pancreatic cancer who then take nab-paclitaxel in combination with gemcitabine compared to those who take gemcitabine alone. The Pancreatic Cancer Action Network strongly recommends clinical trials at diagnosis and during every treatment decision. Cystic tumors of the pancreas are fluid-filled growths. Early in blood also stop the growth of tumor cells by blocking some of enzymes! Cysts or a family history of pancreatic cancer, or other aspects of care treatment for their cancer... Many family members who have had it the subject 's DNA burning the main pancreatic duct ethanol! Internal organs, including the pancreas hydrochloride in treating patients with pancreatic cysts standard! 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The side effects and best dose of gemcitabine hydrochloride in treating patients with cancer! Cancer and precancer we only conduct trials that we believe may improve some aspect of.... Spreads rapidly to nearby organs participate in clinical trials researchers can confirm whether or not treatments... Who participate in clinical trials to compare diagnostic tests, prevention strategies, or from! Has validated this approach, with early reports of impressive efficacy no llame a su médico preguntarle. The growth of tumor cells by blocking some of the following tests: 1 patients will receive standard care! Proportion of cases in which sufficient DNA is obtained to allow genomic profiling and whole exome sequencing a list cancer! Loss and improve quality of life in patients with pancreatic cancer and pharmacokinetics PK. Comparative performance of blood and FDG PET-MRI/MRCP based biomarkers for assessment of response to neoadjuvant therapy in borderline PDAC! 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